ZBTB7A Antibody

APR11232G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR11232G		0.1 mg / ￥6950

大規(guī)格詢(xún)價(jià)

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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ZBTB7A Antibody

品牌	Leading Biology	貨號(hào)	APR11232G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ZBTB7A antibody.
分子量	61439 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
靶點(diǎn)	ZBTB7A; At least two isoforms of ZBTB7A are known to exist; this antibody will recognize both isoforms. This antibody is predicted to not cross-react with other ZBTB protein family members.
亞型	IgG
通用名	FBI1, LRF, ZBTB7, ZNF857A
基因ID	51341
UniProt ID	O95365
功能	Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).
總結(jié)	ZBTB7A Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB7A, also known as LRF, was initially identified as a potential target of the LAZ-3/BCL-6 oncogene. Later reports demonstrated that it could bind to the wild-type IST (inducer of short transcripts) elements of HIV-1 long terminal repeats (LTRs) and stimulate Tat activity on the HIV-1 LTR. More recently it ZBTB7A has been recognized as a proto-oncogene whose overexpression contributes to malignancy in breast cancer and functions as a co-repressor of the androgen receptor in prostate cancer cells.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
圖像	Western blot analysis of ZBTB7A in human ovary tissue lysate with ZBTB7A antibody at (A) 1 and (B) 2 μg/mL. Immunohistochemistry of ZBTB7A in human ovary tissue with ZBTB7A antibody at 2.5 μg/mL. Immunofluorescence of ZBTB7A in human ovary tissue with ZBTB7A antibody at 20 μg/mL.
說(shuō)明書(shū)	Product Datasheet Protocol
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