EGFR Antibody (Y1092)

APR05963G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR05963G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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EGFR Antibody (Y1092)

品牌	Leading Biology	貨號(hào)	APR05963G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality EGFR Antibody (Y1092).
分子量	134277 Da
細(xì)胞定位	Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF)
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	1070-1099 aa
靶點(diǎn)	This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1070-1099 amino acids from human EGFR.
亞型	Rabbit Ig
通用名	ERBB, ERBB1, HER1
基因ID	1956
UniProt ID	P00533
功能	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.
總結(jié)	The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	IHC-P~~1:25 WB~~1:1000
圖像	Immunohistochemical analysis of paraffin-embedded H. stomach section using EGFR Antibody (Y1092)( APR05963G). APR05963G was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining. EGFR Antibody (pY1092) (Cat. APR05963G) western blot analysis in A431 cell line lysates (35ug/lane).This demonstrates the EGFR antibody detected the EGFR protein (arrow). EGFR Antibody (pY1092) (Cat. APR05963G) western blot analysis in A431,Hela,HUVEC,PC-3 cell line lysates (35ug/lane).This demonstrates the EGFR antibody detected the EGFR protein (arrow).
說明書	Product Datasheet Protocol
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