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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Metabotropic Glutamate Receptor 2/3 Antibody品牌 |
Leading Biology | 貨號(hào) |
AMM06383G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Metabotropic Glutamate Receptor 2/3 antibody.
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分子量 |
110/220 KDa
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Rat
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靶點(diǎn) |
Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
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基因ID |
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UniProt ID |
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總結(jié) |
The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR2 subunit has been shown to be required for long-term potentiation at the mossy fiber input in the hippocampus (Yokoi et al., 1996).
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形式 |
Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC
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稀釋方法 |
IHC~~1:500
WB~~ 1:1000
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別名 |
Metabotropic glutamate receptor 2, mGluR2, Grm2, Gprc1b, Mglur2
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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