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當(dāng)前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Metabotropic Glutamate Receptor 1a Antibody

Metabotropic Glutamate Receptor 1a Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
AMM06382G 100 μl / ¥5450

Metabotropic Glutamate Receptor 1a Antibody

品牌

Leading Biology

貨號(hào)

AMM06382G

產(chǎn)品分類

Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Metabotropic Glutamate Receptor 1a antibody.

分子量

125/250 KDa

宿主

Rabbit

種屬反應(yīng)性

Mouse, Rat

靶點(diǎn)

Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.

基因ID

UniProt ID

總結(jié)

The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003).

形式

Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB

稀釋方法

WB~~ 1:1000

別名

Metabotropic glutamate receptor 1, mGluR1, Grm1, Gprc1a, Mglur1

圖像

Western blot of 10 ug of HEK 293 cells expressing mGluR1a and mGluR5 showing the specific immunolabeling of the ~125k monomer and the ~250k dimer of mGluR1a. The mGluR1a antibody shows no reactivity toward mGluR5.

說明書

數(shù)量

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