STAT3 Antibody (C-term S727)

APR11199G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR11199G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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STAT3 Antibody (C-term S727)

品牌	Leading Biology	貨號(hào)	APR11199G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STAT3 antibody (C-term S727).
分子量	88068 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 Identified in a complex with LYN and PAG1
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	711-743 aa
靶點(diǎn)	This STAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide from the C-terminal region of human STAT3, aa 711-743.
亞型	Rabbit Ig
通用名	APRF
基因ID	6774
UniProt ID	P40763
功能	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
總結(jié)	The protein encoded by this gene is a member of the STATprotein family. In response to cytokines and growth factors, STATfamily members are phosphorylated by the receptor associatedkinases, and then form homo- or heterodimers that translocate tothe cell nucleus where they act as transcription activators. Thisprotein is activated through phosphorylation in response to variouscytokines and growth factors including IFNs, EGF, IL5, IL6, HGF,LIF and BMP2. This protein mediates the expression of a variety ofgenes in response to cell stimuli, and thus plays a key role inmany cellular processes such as cell growth and apoptosis. Thesmall GTPase Rac1 has been shown to bind and regulate the activityof this protein. PIAS3 protein is a specific inhibitor of thisprotein. Three alternatively spliced transcript variants encodingdistinct isoforms have been described.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IF, WB, E
稀釋方法	WB~~1:1000 IF~~1:200
別名	Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF
圖像	STAT3 Antibody (pS727) (Cat. APR11199G) western blot analysis in Daudi cell line lysates (35ug/lane).This demonstrates the STAT3 antibody detected the STAT3 protein (arrow). Fluorescent confocal image of SY5Y cells stained with STAT3 (C-term S727) antibody. SY5Y cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then incubated with APR11199G STAT3 (C-term S727) primary antibody (1:200, 2 h at room temperature). For secondary antibody, Alexa Fluor? 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Nuclei were counterstained with Hoechst 33342 (blue) (10 μg/ml, 5 min). Note the highly specific localization of the STAT3 mainly to the nucleus, supported by Human Protein Atlas Data (http://www.proteinatlas.org/ENSG00000168610).
說(shuō)明書(shū)	Product Datasheet Protocol
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