MUC20 Antibody (C-term)

APR14363G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR14363G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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MUC20 Antibody (C-term)

品牌	Leading Biology	貨號(hào)	APR14363G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MUC20 antibody (C-term).
分子量	71982 Da
細(xì)胞定位	Antigen Cellular Localization: Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	654-684 aa
靶點(diǎn)	This MUC20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-684 amino acids from the C-terminal region of human MUC20.
亞型	Rabbit Ig
通用名	KIAA1359
基因ID	200958
UniProt ID	Q8N307
功能	May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
總結(jié)	This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in different individuals. Multiple transcript variants encoding different isoforms have been found for this gene.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, FC, E
稀釋方法	WB~~1:1000 IHC-P~~1:10~50 IF~~1:10~50 FC~~1:10~50
別名	Mucin-20, MUC-20, MUC20, KIAA1359
圖像	MUC20 Antibody (C-term) (Cat. APR14363G) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the MUC20 antibody detected the MUC20 protein (arrow). MUC20 Antibody (C-term) (Cat. APR14363G)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MUC20 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Confocal immunofluorescent analysis of MUC20 Antibody (C-term)( APR14363G) with WiDr cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
說(shuō)明書(shū)	Product Datasheet Protocol
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