全部產品分類
品牌 |
Leading Biology | 貨號 |
APR14295G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MUC20 antibody (N-term).
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分子量 |
71982 Da
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細胞定位 |
Antigen Cellular Localization:
Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane
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宿主 |
Rabbit
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種屬反應性 |
Human
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免疫原 |
61-90 aa
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靶點 |
This MUC20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the N-terminal region of human MUC20.
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亞型 |
Rabbit Ig
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通用名 |
KIAA1359
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基因ID |
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UniProt ID |
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功能 |
May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
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總結 |
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in different individuals. Multiple transcript variants encoding different isoforms have been found for this gene.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IF, E
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稀釋方法 |
WB~~1:1000
IF~~1:10~50
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別名 |
Mucin-20, MUC-20, MUC20, KIAA1359
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圖像 |
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說明書 |
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數(shù)量 |
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