全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR11763G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DMPK antibody (N-term).
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分子量 |
69385 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Cytoplasmic side. Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Single-pass type IV membrane protein Sarcoplasmic reticulum membrane. Cell membrane. Cytoplasm, cytosol. Note=Localizes to sarcoplasmic reticulum membranes of cardiomyocytes. Isoform 3: Mitochondrion membrane.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
11-39 aa
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靶點 |
This DMPK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human DMPK.
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亞型 |
Rabbit Ig
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通用名 |
DM1PK, MDPK
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基因ID |
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UniProt ID |
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功能 |
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
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總結(jié) |
The protein encoded by this gene is a serine-threoninekinase that is closely related to other kinases that interact withmembers of the Rho family of small GTPases. Substrates for thisenzyme include myogenin, the beta-subunit of the L-type calciumchannels, and phospholemman. The 3' untranslated region of thisgene contains 5-37 copies of a CTG trinucleotide repeat. Expansionof this unstable motif to 50-5,000 copies causes myotonic dystrophytype I, which increases in severity with increasing repeat elementcopy number. Repeat expansion is associated with condensation oflocal chromatin structure that disrupts the expression of genes inthis region. Several alternatively spliced transcript variants ofthis gene have been described, but the full-length nature of someof these variants has not been determined.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Myotonin-protein kinase, MT-PK, DM-kinase, DMK, DM1 protein kinase, DMPK, Myotonic dystrophy protein kinase, DMPK, DM1PK, MDPK
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圖像 |
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說明書 |
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數(shù)量 |
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