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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR11078G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ERVWE1 antibody (C-term).
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分子量 |
59866 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Transmembrane protein: Cell membrane; Single-pass type I membrane protein Syncytin-1: Virion.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
493-521 aa
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靶點(diǎn) |
This ERVWE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-521 amino acids from the C-terminal region of human ERVWE1.
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亞型 |
Rabbit Ig
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通用名 |
ERVWE1
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基因ID |
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UniProt ID |
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功能 |
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).
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總結(jié) |
Many different human endogenous retrovirus (HERV) familiesare expressed in normal placental tissue at high levels, suggestingthat HERVs are functionally important in reproduction. This gene ispart of an HERV provirus on chromosome 7 that has inactivatingmutations in the gag and pol genes. This gene is the envelopeglycoprotein gene which appears to have been selectively preserved.The gene's protein product is expressed in the placentalsyncytiotrophoblast and is involved in fusion of thecytotrophoblast cells to form the syncytial layer of the placenta.The protein has the characteristics of a typical retroviralenvelope protein, including a furin cleavage site that separatesthe surface (SU) and transmembrane (TM) proteins which form aheterodimer. Alternatively spliced transcript variants encoding thesame protein have been found for this gene.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q212 provirus ancestral Env polyprotein, Syncytin, Surface protein, SU, gp50, Transmembrane protein, TM, gp24, ERVW-1, ERVWE1
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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