EGLN2 Antibody (N-term)

APR07646G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR07646G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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EGLN2 Antibody (N-term)

品牌	Leading Biology	貨號(hào)	APR07646G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality EGLN2 antibody (N-term).
分子量	43650 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	96-123 aa
靶點(diǎn)	This EGLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the N-terminal region of human EGLN2.
亞型	Rabbit Ig
通用名	EIT6
基因ID	112398
UniProt ID	Q96KS0
功能	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferencially recognized via a LXXLAP motif.
總結(jié)	The hypoxia inducible factor (HIF) is a transcriptionalcomplex which is involved in oxygen homeostasis. At normal oxygenlevels, the alpha subunit of HIF is targeted for degration byprolyl hydroxylation. This gene encodes an enzyme responsible forthis posttranslational modification. Multiple alternatively splicedvariants, encoding the same protein, have been identified.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Egl nine homolog 2, Estrogen-induced tag 6, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 1, HIF-PH1, HIF-prolyl hydroxylase 1, HPH-1, Prolyl hydroxylase domain-containing protein 1, PHD1, EGLN2, EIT6
圖像	EGLN2 Antibody (N-term) (Cat. APR07646G) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the EGLN2 antibody detected the EGLN2 protein (arrow).
說(shuō)明書	Product Datasheet Protocol
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