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全部產(chǎn)品分類(lèi)
品牌 |
Leading Biology | 貨號(hào) |
AMM07512G |
產(chǎn)品分類(lèi) |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RAMP3 antibody (C-term).
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分子量 |
16518 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein Membrane; Single-pass type I membrane protein. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse
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免疫原 |
90-118 aa
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靶點(diǎn) |
This RAMP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-118 amino acids from the C-terminal region of human RAMP3.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
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總結(jié) |
The protein encoded by this gene is a member of the RAMPfamily of single-transmembrane-domain proteins, called receptor(calcitonin) activity modifying proteins (RAMPs). RAMPs are type Itransmembrane proteins with an extracellular N terminus and acytoplasmic C terminus. RAMPs are required to transportcalcitonin-receptor-like receptor (CRLR) to the plasma membrane.CRLR, a receptor with seven transmembrane domains, can function aseither a calcitonin-gene-related peptide (CGRP) receptor or anadrenomedullin receptor, depending on which members of the RAMPfamily are expressed. In the presence of this (RAMP3) protein, CRLRfunctions as an adrenomedullin receptor.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:2000
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別名 |
Receptor activity-modifying protein 3, Calcitonin-receptor-like receptor activity-modifying protein 3, CRLR activity-modifying protein 3, RAMP3
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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