全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR11935G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FREQ antibody (N-term).
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分子量 |
21879 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
1-30 aa
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靶點 |
This FREQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FREQ.
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亞型 |
Rabbit Ig
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通用名 |
FLUP, FREQ
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基因ID |
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UniProt ID |
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功能 |
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity).
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總結(jié) |
This gene is a member of the neuronal calcium sensor genefamily, which encode calcium-binding proteins expressedpredominantly in neurons. The protein encoded by this generegulates G protein-coupled receptor phosphorylation in acalcium-dependent manner and can substitute for calmodulin. Theprotein is associated with secretory granules and modulatessynaptic transmission and synaptic plasticity. Multiple transcriptvariants encoding different isoforms have been found for this gene.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:10~50
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別名 |
Neuronal calcium sensor 1, NCS-1, Frequenin homolog, Frequenin-like protein, Frequenin-like ubiquitous protein, NCS1, FLUP, FREQ
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圖像 |
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說明書 |
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數(shù)量 |
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