全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR13728G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TGIF1 antibody (N-term).
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分子量 |
43013 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
81-109 aa
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靶點 |
This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human TGIF1.
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亞型 |
Rabbit Ig
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通用名 |
TGIF
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基因ID |
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UniProt ID |
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功能 |
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
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總結(jié) |
The protein encoded by this gene is a member of thethree-amino acid loop extension (TALE) superclass of atypicalhomeodomains. TALE homeobox proteins are highly conservedtranscription regulators. This particular homeodomain binds to apreviously characterized retinoid X receptor responsive elementfrom the cellular retinol-binding protein II promoter. In additionto its role in inhibiting 9-cis-retinoic acid-dependent RXR alphatranscription activation of the retinoic acid responsive element,the protein is an active transcriptional co-repressor of SMAD2 andmay participate in the transmission of nuclear signals duringdevelopment and in the adult. Mutations in this gene are associatedwith holoprosencephaly type 4, which is a structural anomaly of thebrain. Alternative splicing has been observed at this locus andeight variants, encoding four distinct isoforms, are described.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF
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圖像 |
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說明書 |
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數(shù)量 |
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