全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR11832G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ENSA antibody (Center).
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分子量 |
13389 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse
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免疫原 |
39-66 aa
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靶點(diǎn) |
This ENSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human ENSA.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
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總結(jié) |
ENSA belongs to a highlyconserved cAMP-regulated phosphoprotein (ARPP) family. This proteinwas identified as an endogenous ligand for the sulfonylureareceptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of theATP-sensitive potassium (KATP) channel, which is located on theplasma membrane of pancreatic beta cells and plays a key role inthe control of insulin release from pancreatic beta cells. Thisprotein is thought to be an endogenous regulator of KATP channels.In vitro studies have demonstrated that this protein modulatesinsulin secretion through the interaction with KATP channel, andthis gene has been proposed as a candidate gene for type 2diabetes.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, FC, E
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稀釋方法 |
WB~~1:1000
FC~~1:10~50
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別名 |
Alpha-endosulfine, ARPP-19e, ENSA
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圖像 |
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說明書 |
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數(shù)量 |
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