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當(dāng)前位置:首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > ERN2 Antibody (N-term)

ERN2 Antibody (N-term)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢(xún)價(jià)
APR05846G 100 μl / ¥4950

ERN2 Antibody (N-term)

品牌

Leading Biology

貨號(hào)

APR05846G

產(chǎn)品分類(lèi)

Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ERN2 Antibody (N-term).

分子量

102480 Da

細(xì)胞定位

Antigen Cellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein

宿主

Rabbit

種屬反應(yīng)性

Human

免疫原

39-72 aa

靶點(diǎn)

This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2.

亞型

Rabbit Ig

基因ID

UniProt ID

功能

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

總結(jié)

ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, E

稀釋方法

WB~~1:1000

圖像

Western blot analysis of lysate from HT-29 cell line, using ERN2 Antibody (N-term)(APR05846G). APR05846G was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35ug.

Western blot analysis of ERN2 N-term (Cat. APR05846G) in mouse stomach tissue lysates (35ug/lane). ERN2 (arrow) was detected using the purified Pab.

說(shuō)明書(shū)

數(shù)量

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