NAE1 Antibody (Center)

APR03771G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR03771G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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NAE1 Antibody (Center)

品牌	Leading Biology	貨號(hào)	APR03771G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NAE1 Antibody (Center).
分子量	60246 Da
細(xì)胞定位	Antigen Cellular Localization: Cell membrane. Note=Colocalizes with APP in lipid rafts
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	172-200 aa
靶點(diǎn)	This NAE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the Central region of human NAE1.
亞型	Rabbit Ig
通用名	APPBP1
基因ID	8883
UniProt ID	Q13564
功能	Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
總結(jié)	The protein encoded by this gene binds to the beta-amyloidprecursor protein. Beta-amyloid precursor protein is a cell surfaceprotein with signal-transducing properties, and it is thought toplay a role in the pathogenesis of Alzheimer's disease. Inaddition, the encoded protein can form a heterodimer with UBE1C andbind and activate NEDD8, a ubiquitin-like protein. This protein isrequired for cell cycle progression through the S/M checkpoint.Three transcript variants encoding different isoforms have beenfound for this gene.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	WB~~1:1000 IHC-P~~1:10~50
圖像	NAE1 Antibody (Center) (Cat. APR03771G) western blot analysis in K562,293 cell line lysates (35ug/lane).This demonstrates the NAE1 antibody detected the NAE1 protein (arrow). NAE1 Antibody (Center) (Cat. APR03771G)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NAE1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
說(shuō)明書	Product Datasheet Protocol
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