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NT3 Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢(xún)價(jià)
AMM06838G 50 μl / ￥6950

NT3 Antibody

品牌

 Leading Biology

貨號(hào)

 AMM06838G

產(chǎn)品分類(lèi)

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NT3 antibody.

分子量
29355 Da

宿主
Rabbit

種屬反應(yīng)性
Human, Mouse, Rat

靶點(diǎn)
Peptide GEIKTGNSPV(C),??corresponding to amino acid residues 39-48 of mature human NT-3??(residues 177-186 of the NT-3 precursor) (Accession P20783).

基因ID

UniProt ID

總結(jié)
The neurotrophins ("neuro" means nerve and "trophe" means nutrient) are a family of soluble,basic growth factors which regulate neuronal development, maintenance, survival and death in the CNS and the PNS.1 The structural hallmark of all the neurotrophins is the characteristicarrangement of the disulfide bridges known as the cysteine knot, which has been found in othergrowth factors such as PDGF.2 The rat and human forms of Neurotrophin-3 (NT-3) are 96% homologous. NT-3 has been shown to strengthen synaptic connections to motoneurons in the neonatal rat,3to serve as an anti-inflammatory factor, to suppress microglial activation,4 to play a criticalrole in regulating T helper 1/T helper 2 cell balance5 and to modify potassium currents in isolated inner hair cells from guinea pig cochlea.6 The biological effects of NT-3 are mediatedby two receptors: TrkC, which is specific for NT-3, and p75NTR, which binds all the neurotrophins.7

形式
Affinity purified antibody, Liquid

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB

稀釋方法
WB~~1:200-1:2000

別名
Neurotrophin-3, NT-3, HDNF, Nerve growth factor 2, NGF-2, Neurotrophic factor, NTF3

圖像

Western blot analysis using Anti-NT-3 antibody (1:1000) (1-4) or anti-NT-3 antibody, preincubated with the control antigen peptide (5): 1. hNT-3 ( N-260), 10 ng 2. hß-NGF ( N-245), 100 ng 3. hNT-4 ( N-260), 100 ng 4. hNT-3 ( N-260), 10 ng 5. Control peptide

Expression of NT-3 in mouse spinal cord Immunohistochemical staining of mouse spinal cord using Anti-NT-3 antibody ( AMM06838G). The spinal ventral horn was stained diffusely with some extensions (arrows) into the white matter (WM). In the WM there were NT-3 immunoreactive cells that were probably glia (triangles).

說(shuō)明書(shū)

數(shù)量

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