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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
AMM06839G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NT4 antibody.
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分子量 |
22427 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse
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靶點(diǎn) |
Peptide LGEVPAAGGSPL(C), corresponding to amino acid residues 43-52 of mature human NT-4??(123-132 of the precursor NT-4)??(Accession P34130).
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基因ID |
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UniProt ID |
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總結(jié) |
The neurotrophins ("neuro" means nerve and "trophe" means nutrient) are a family of soluble,basic growth factors which regulate neuronal development, maintenance, survival and death inthe CNS and the PNS.1 Neurotrophin-4 (NT-4) is expressed in neurons of the superior cervical,stellate and celiac ganglion,2 T-cells3 and is synthesized by keratinocytes.4The structural hallmark of all the neurotrophins is the characteristic arrangement of thedisulfide bridges known as the cysteine knot, which has been found in other growth factorssuch as PDGF.5 The rat and human forms of NT-4 are 96% homologous. NT-4 has been shown topromote dendritic outgrowth and calcium currents in cultured mesencephalic dopamine neurons,6to promote growth and remodeling of adult motor neuron innervation,7 to be anterogradesurvival factors for postsynaptic cells8 and to protect against apoptotic neuronal death.9 The biological effects of NT-4 are mediated by two receptors: TrkB, which is specific forNT-4 and BDNF, and p75 which binds all the neurotrophins.10
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形式 |
Affinity purified antibody, Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:200-1:2000
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別名 |
Neurotrophin-4, NT-4, Neurotrophin-5, NT-5, Neutrophic factor 4, NTF4, NTF5
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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