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當(dāng)前位置：首頁 > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > proNT-3 Antibody

proNT-3 Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR12981G 50 μl / ￥6950

proNT-3 Antibody

品牌

 Leading Biology

貨號(hào)

 APR12981G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality proNT-3 antibody.

分子量
29355 Da

宿主
Rabbit

種屬反應(yīng)性
Mouse, Rat

靶點(diǎn)
Peptide (C)DTELLRQQRRYNSPR, corresponding to amino acid residues 89-103 of human NT-3 (precursor) (Accession P20783).??Pro domain of the NT-3 protein.The antibody is specific for proNT-3, it does not crossreact with proNGF, proBDNF or mature NT-3.

基因ID

UniProt ID

總結(jié)
Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes nerve growth factor (NGF) neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5).All neurotrophins are synthesized as preproneurotrophin precursors that are subsequently processed within the intracellular transport pathway to yield proneurotrophins that are further processed to generate the mature form. The mature form of BDNF is a non-covalent stable homodimer that can be secreted in both constitutive and regulated pathways.Until recently, the functional role of the neurotrophins prodomains was thought to include assistance in the correct folding of the mature protein and the sorting of the neurotrophins into the constitutive or regulated secretory pathway. However, a growing body of evidence suggests that the uncleaved proneurotrophin precursors can be secreted from cells and that they may mediate different biological functions.Several studies implicate both proNGF and proBDNF in several physiological and pathological conditions.Today it remains to be established whether proNT-3 has similarly, different biological functions than the mature NT-3 neurotrophin.Abgent has now developed a new antibody directed against a highly specific epitope located in the pro domain region of human NT-3. The antibody does not cross reacts with mature NT-3, pro and mature NGF or pro and mature BDNF.

形式
Affinity purified antibody, Liquid

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB

稀釋方法
WB~~1:200-1:2000

別名
Neurotrophin-3, NT-3, HDNF, Nerve growth factor 2, NGF-2, Neurotrophic factor, NTF3

圖像

Western blot analysis using Anti-proNT-3 antibody ( APR12981G) (1:600): 1. hNT-3 ( N-260), (200 ng). 2. hNT-4 ( N-270), (200 ng). 3. mNGF 2.5S (Grade II) ( N-100), (200 ng). 4. hß-NGF ( N-245), (200 ng). 5. hBDNF ( B-250), (200 ng). 6. proNGF (WT-mouse) ( N-250), (200 ng). 7. proBDNF (WT-mouse) ( B-240), (200 ng). 8. recombinant proNT-3 10 ng.

Western blot analysis of mouse recombinant proNT-3: 1, 5. 10 ng proNT-3. 2, 6. 50 ng proNT-3. 3, 7. 100 ng proNT-3. 4, 8. 200 ng proNT-3. Lanes 1-4 Anti-proNT-3 antibody ( APR12981G), (1:300). Lanes 5-8 Anti-proNT-3 antibody, preincubated with the control peptide antigen.

Expression of proNT-3 in rat brain Immunohistochemical staining of rat Islands of Calleja (IOC) using Anti-proNT-3 antibody ( APR12981G). A. proNT-3 staining (green) overlaps neuronal nitric oxide synthase (nNOS red) while a cluster of cells covers a part of the island (DAPI blue counterstain) but not a cell-poor area (star). B. The distribution of proNT-3 is shown alone. Note that staining is more intense in the cell poor area demarcated by white line. C. The distribution of neuronal NOS is most intense in the cell-poor region.

說明書

數(shù)量

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