Nephrin Antibody

APR17562G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR17562G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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Nephrin Antibody

品牌	Leading Biology	貨號(hào)	APR17562G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Nephrin antibody.
分子量	Predicted: 125, 137 kDa Observed: 125 kDa
細(xì)胞定位	Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	NPHS1; Nephrin antibody is human specific.
亞型	IgG
通用名	NPHN
基因ID	4648
UniProt ID	O60500
功能	Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity).
總結(jié)	Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth (1). Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm (2,3).
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, IF, E
圖像	Western blot analysis of Nephrin in human kidney tissue lysate with Nephrin antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide. Immunohistochemistry of Nephrin in human kidney tissue with Nephrin antibody at 5 μg/ml. Immunofluorescence of Nephrin in human kidney tissue with Nephrin antibody at 20 μg/ml.
說(shuō)明書(shū)	Product Datasheet Protocol
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