RPSA Antibody

APR13151G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR13151G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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RPSA Antibody

品牌	Leading Biology	貨號	APR13151G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RPSA antibody.
分子量	Predicted: 32 kDa Observed: 38 kDa
細胞定位	Antigen Cellular Localization: Cell membrane. Cytoplasm. Nucleus {ECO:0000255\|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin- binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane {ECO:0000255\|HAMAP-Rule:MF_03016}
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
靶點	RPSA; RPSA antibody is human, mouse and rat reactive.
亞型	IgG
通用名	LAMBR, LAMR1
基因ID	3921
UniProt ID	P08865
功能	Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
總結(jié)	The 40S ribosomal protein SA (RPSA) is a high-affinity, non-integrin family, laminin receptor, also known as 67 kDa laminin receptor or 37 kDa laminin receptor precursor (37LRP) (1). Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes and have been implicated in a variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis (2). RPSA is overexpressed in multiple types of cancers and has recently been shown to act as a cancer-specific death receptor (3).
形式	Liquid
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
圖像	Western blot analysis of RPSA in HepG2 cell lysate with RPSA antibody at (A) 1 and (B) 2 μg/ml. Immunohistochemistry of RPSA in mouse liver tissue with RPSA antibody at 5 μg/mL. Immunofluorescence of RPSA in mouse liver tissue with RPSA antibody at 20 μg/mL.
說明書	Product Datasheet Protocol
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