TCTN1 Antibody

APR13723G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR13723G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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TCTN1 Antibody

品牌	Leading Biology	貨號(hào)	APR13723G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TCTN1 antibody.
分子量	63570 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm, cytoskeleton, cilium basal body. Secreted. Note=Despite the presence of a signal sequence, the full length protein might not be secreted. Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
靶點(diǎn)	TCTN1;
亞型	IgG
通用名	TECT1
基因ID	79600
UniProt ID	Q2MV58
功能	Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity).
總結(jié)	TCTN1 Antibody: TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
圖像	Western blot analysis of TCTN1 in mouse kidney tissue lysate with TCTN1 antibody at (A) 1 and (B) 2 μg/mL. Immunohistochemistry of TCTN1 in human kidney tissue with TCTN1 antibody at 5 μg/mL. Immunofluorescence of TCTN1 in Human Kidney cells with TCTN1 antibody at 20 μg/mL.
說(shuō)明書	Product Datasheet Protocol
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