Mcl-1 Antibody

APR08378G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR08378G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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Mcl-1 Antibody

品牌	Leading Biology	貨號(hào)	APR08378G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mcl-1 antibody.
分子量	37337 Da
細(xì)胞定位	Antigen Cellular Localization: Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	MCL1; Detects isoforms Mcl-1L and Mcl-1S
亞型	IgG
通用名	BCL2L3
基因ID	4170
UniProt ID	Q07820
功能	Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
總結(jié)	Mcl-1 Antibody: Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least three distinct isoforms designated Mcl-1L, Mcl-1S and Mcl-1ES. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, ICC, E
別名	Mcl-1 Antibody: TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3, MCL1-ES, bcl2-L-3, mcl1/EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, myeloid cell leukemia sequence 1 (BCL2-related)
圖像	Western blot analysis of Mcl-1 in Raji cell lysates with Mcl-1 antibody (IN) at (A) 0.5, (B) 1, and (C) 2 μg/mL. Immunocytochemistry of Mcl-1 in Raji cells with Mcl-1 antibody at 10 μg/mL.
說(shuō)明書(shū)	Product Datasheet Protocol
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