PAK6 Antibody

APR17743G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR17743G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

Tel: 400-965-8633
Tel: 010-56256916
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PAK6 Antibody

品牌	Leading Biology	貨號(hào)	APR17743G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PAK6 antibody.
分子量	Predicted: 75 kDa Observed: 70 kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	PAK6; PAK6 antibody is predicted to not cross-react with other PAK family proteins.
亞型	IgG
通用名	PAK5
基因ID	56924
UniProt ID	Q9NQU5
功能	Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
總結(jié)	PAK6 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
別名	PAK6 Antibody: PAK5, PAK5, PAK-5, PAK-6, p21 protein (Cdc42/Rac)-activated kinase 6
圖像	Western blot analysis of PAK6 in Raji lysate with PAK6 antibody at (A) 1, (B) 2, and (C) 4 μg/mL. Immunocytochemistry of PAK6 in Raji cells with PAK6 antibody at 10 μg/mL. Immunofluorescence of PAK6 in Raji cells with PAK6 antibody at 10 μg/mL.
說明書	Product Datasheet Protocol
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