全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM06001G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HCN4 antibody.
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分子量 |
129042 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點(diǎn) |
GST fusion protein with sequence HGHLHDSAEERRLIAEGDASPG EDRTPPGLAAEPERP, corresponding to amino acid residues 119-155 of human HCN4 (Accession Q9Y3Q4) , (MW: 31 kDa.).????Intracellular, N-terminus.
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基因ID |
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UniProt ID |
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總結(jié) |
Hyperpolarization-activated cation currents (Ih) appear in the heart and the brain and have a crucial role in controlling electrical pacemaker activity, contributing to biological processes such as heartbeat, sleep-wake cycle and synaptic plasticity.1,2The Ihcurrents are generated by the Hyperpolarization-activated cyclic nucleotide-gated channel family (HCN), which is comprised of four homologous members,HCN1-4.EachHCNsubunit consists of six transmembrane domains (TM), a pore region between TM5-TM6 and a binding domain for cyclic nucleotides (CNBD) in the cytoplasmic C-terminus.2TheHCNsubunits can form functional homomers and can also co-assemble into functional heteromers.2The channels are closely related to each other and share a homology of about 60%. However, their similarity decreases in the cytoplasmic N- and C-termini. TheHCN1-4 channels mainly differ from each other in their speed of activation and the extent to which they are modulated by cAMP.HCN1, weakly affected by cAMP, is the fastest channel, followed byHCN2,HCN3 andHCN4.HCN4 is highly expressed in a restricted manner in adult sinoatrial (SA) node, constituting a goodmolecular marker for the adult cardiac pacemaker and might serve as a unique marker of the developing SA node .4,5mRNA expression of HCN4is most abundant in medial habenula and anterior and principal relay nuclei of the thalamus.6
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形式 |
Affinity purified antibody, Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IP
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稀釋方法 |
WB~~1:200-1:2000
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別名 |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, HCN4
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圖像 |
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說明書 |
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數(shù)量 |
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