總結(jié) |
The P2Y receptors belong to the G-protein coupled receptors superfamily.P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP) and regulate several physiologic responses, among them, cardiac function, platelet aggregation and SMC proliferation.1The mammalian P2Y family currently includes eight functional receptors; P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and the UDP-glucose receptor, now renamed P2Y14.2-4P2Y1 receptor is abundantly expressed in a number of tissues. In platelets, P2Y1 receptor is co-expressed with P2Y12 receptor, responsible for the initial shape change, aggregation, and rise in intracellular Ca2+ upon activation in response to ADP.5Abgent is please to offer a highly specific antibody directed againstan extracellular epitope of humanP2Y1 receptor.Anti-P2Y1 Receptor (extracellular)antibody (#AG1398) can be used in western blot analysisandindirect flow cytometryapplications, and has been designed to recognize P2Y1 from mouse, rat and human samples.
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