品牌 |
Leading Biology | 貨號(hào) |
APR13809G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRPC4 antibody.
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分子量 |
111575 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點(diǎn) |
Peptide (C)KEKHAHEEDSSIDYDL, corresponding to amino acid residues 943-958 of mouse TRPC4 (Accession number Q9QUQ5).????Intracellular, C-terminus.
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基因ID |
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UniProt ID |
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總結(jié) |
The Transient Receptor Potential (TRP) superfamily is one of the largest ion channel families and consists of diverse groups of proteins. In mammals about 28 genes encode the TRP ion channel subunits. The mammalian TRP superfamily comprises six subfamilies known as the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipins), TRPP (polycystin) and the TRPA (ANKTM1) ion channels.1-4The TRPC subfamily consists of seven proteins named TRPC1 to 7 which can be further divided into four subgroups based on their sequence homology and functional similarities:1. TRPC12. TRPC4 and TRPC53. TRPC3, TRPC6, TRPC74. TRPC2.2,5They are highly expressed in the central nervous system and to a lesser extent in peripheral tissues.TRPC4 can form heterotetramers with TRPC1. TRPC4, TRPC1 and TRPC5 can be activated either by calcium store depletion or by GPCR stimulation pathways and are also assumed to form components of store operated channels in some cell types such as salivary gland cells, endothelial cells and vascular smooth muscle cells.6
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形式 |
Affinity purified antibody, Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IP
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稀釋方法 |
WB~~1:200-1:2000
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別名 |
Short transient receptor potential channel 4, TrpC4, Capacitative calcium entry channel Trp4, Receptor-activated cation channel TRP4, Trpc4, Trrp4
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圖像 |
Western blot analysis of rat brain membranes: 1. Anti-TRPC4 antibody ( APR13809G), (1:200). 2. Anti-TRPC4 antibody, preincubated with the control peptide antigen. Western blot analysis of PC3 (lanes 1,3) and LNCaP cell lysates: 1. Anti-TRPC4 antibody ( APR13809G), (1:200). 2. Anti-TRPC4 antibody, preincubated with the control peptide antigen. Immunoprecipitation of rat brain lysate: 1. Rat brain lysate. 2. Lysate immunoprecipitated with Anti-TRPC4 antibody ( APR13809G), (6 mg). 3. Lysate immunoprecipitated with pre-immune rabbit serum. The upper arrow indicates the TRPC4 channel while the lower arrow indicates the IgG heavy chain. Western blot analysis was performed with Anti-TRPC4 antibody. |
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說明書 |
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數(shù)量 |
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