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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > GABA Transporter 1 (GAT-1) (extracellular) Antibody品牌 |
Leading Biology | 貨號 |
APR11958G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GABA Transporter 1 (GAT-1) (extracellular) antibody.
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分子量 |
67001 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點 |
Peptide (C)ERNMHQMTDGLDK, corresponding to amino acids residues 194-206 of rat GABA Transporter?? 1 (Accession P23978). 2nd?? extracellular loop.
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基因ID |
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UniProt ID |
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總結(jié) |
γ-aminobutiric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. Transmission via GABA can be halted by its reuptake through GABA transporters (GATs). These membrane proteins belong to the super family of slc6 genes which encode transporters responsible for the uptake of dopamine, serotonin, norepinephrine, glycine and GABA in a Na+-dependent manner1,2.To date, four GATs have been identified: GAT-1, GAT-2, GAT-3 and BGT-1. Like all members of the slc6 family, they have twelve transmembrane domains and short intracellular N- and C-termini1. GATs couple the transport of one GABA molecule to 2Na+ ions and one Cl- ion3. GAT-1 activity can be regulated at the level of its plasma membrane expression which is in part regulated by its trafficking via phosphorylation of residues in intracellular loops1.GAT-1 expression is restricted to the central nervous system, specifically to axon terminals, in the neocortex and in some astrocytic processes4.GAT-1 may be implicated in various psychological and neurological disorders such as schizophrenia, epilepsy and cerebral ischemia1,5-7.Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of rat GABA Transporter 1. Anti-GABA Transporter 1 (GAT-1) (extracellular) antibody (#AG1234) can be used in western blot analysis, and has been designed to recognize GAT-1 from rat, mouse and human samples.
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形式 |
Affinity purified antibody, Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:200-1:2000
IHC~~1:200
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別名 |
Sodium- and chloride-dependent GABA transporter 1, GAT-1, Solute carrier family 6 member 1, Slc6a1, Gabt1, Gat-1, Gat1
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圖像 |
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說明書 |
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數(shù)量 |
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