NaV1.2 Antibody

AMM06561G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM06561G		50 μl / ￥6950

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NaV1.2 Antibody

品牌	Leading Biology	貨號(hào)	AMM06561G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NaV1.2 antibody.
分子量	227874 Da
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	Peptide (C)ASAESRDFSGAGGIGVFSE, corresponding to amino acid residues 467-485 of rat Nav1.2 (Accession P04775).????Intracellular loop between domains I and II .
基因ID	24766
UniProt ID	P04775
總結(jié)	Voltage-gated sodium channels (Nav) are essential for the generation of actionpotentials and for cell excitability.1 Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine Nav α subunits have been cloned and named Nav1.1-Nav1.9.4-5 The Nav channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7) and TTX-resistant (Nav1.5, Nav1.8 and Nav1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6,7Nav1.2 is primarily expressed in the central nervous system (CNS) and is localized in unmyelinated or premyelinated axons and dendrites. Mutations in the Nav1.2 channel have been identified in different types of epilepsy.
形式	Affinity purified antibody, Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IP
稀釋方法	WB~~1:200-1:2000
別名	Sodium channel protein type 2 subunit alpha, Sodium channel protein brain II subunit alpha, Sodium channel protein type II subunit alpha, Voltage-gated sodium channel subunit alpha Nav12, Scn2a, Scn2a1
圖像	Western blot analysis of rat brain membranes: 1. Anti-Na 1.2 antibody ( AMM06561G), (1:200). 2. Anti-Na 1.2 antibody, preincubated with the control peptide antigen. Immunoprecipitation of rat brain lysate: 1. Rat brain lysates 2. Lysates immunoprecipitated with Anti-Na 1.2 antibody ( AMM06561G), (6 g). 3. Lysates immunoprecipitated with pre-immune rabbit serum. The lower arrow indicates the IgG heavy chain. Western blot analysis was performed with Anti-Na 1.2 antibody. Expression of Na 1.2 in mouse hippocampus Immunohistochemical staining of mouse hippocampus using Anti-Na 1.2 antibody ( AMM06561G ). A. Na 1.2 (red) is present in dendrites of pyramidal neurons in the CA3 region. B. Staining of interneurons in the pyramidal layer with mouse anti-Parvalbumin (green) demonstrates the restriction of Na 1.2 to dendrites (arrows) extending from the pyramidal layer (P). C. Confocal merge of panels A and B.
說(shuō)明書(shū)	Product Datasheet Protocol
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