全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM06564G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NaV1.5 antibody.
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分子量 |
227367 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點(diǎn) |
Peptide DRLPKSDSEDGPRALNQLS(C), corresponding to amino acid residues 493-511 of??rat NaV1.5 (accession number P15389). Intracellular loop between domains I and II.
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基因ID |
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UniProt ID |
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總結(jié) |
Voltage-gated Na+ channels (NaV) are responsible for myocardial conduction andmaintenance of the cardiac rhythm and are essential for the generation of actionpotentials and cell excitability.1 Dysfunction or disregulation of cardiac sodium channels can cause several disorders,including cardiac arrhythmias. The majority of Na+ channels in the mammalian heart are Tetrodotoxin (TTX)-insensitive NaV1.5.2The putative structure of NaV1.5 consists of four homologous domains (I-IV),each containing six transmembrane segments (S1-S6).Mutations in the C-terminus of NaV1.5 were described in connection to Long QTsyndrome and Brugada syndrome.1-2Recent data have demonstrated selective expression of NaV1.5 in the mouse centralnervous system and implicated a role for NaV1.5 in the physiology of the centralnervous system.1
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形式 |
Affinity purified antibody, Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IP
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稀釋方法 |
WB~~1:200-1:2000
IHC~~1:100
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別名 |
Sodium channel protein type 5 subunit alpha, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav15, Scn5a
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圖像 |
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說明書 |
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數(shù)量 |
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