全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR09226G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Ser40 Tyrosine Hydroxylase antibody.
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分子量 |
60 KDa
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宿主 |
Rabbit
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種屬反應性 |
Human, Mouse, Rat
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靶點 |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser40 conjugated to KLH.
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基因ID |
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UniProt ID |
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總結 |
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004). The activity of TH is also regulated by phosphorylation (Haycock et al., 1982; Haycock et al., 1992; Jedynak et al., 2002). Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.
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形式 |
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC
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稀釋方法 |
WB~~ 1:1000
IHC~~ 1:1000
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別名 |
Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, TH, Th
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圖像 |
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說明書 |
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數(shù)量 |
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