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當(dāng)前位置:首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > DARPP-32 Antibody

DARPP-32 Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
AMM05829G 100 μl / ¥5450

DARPP-32 Antibody

品牌

Leading Biology

貨號(hào)

AMM05829G

產(chǎn)品分類

Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DARPP-32 antibody.

分子量

32 KDa

宿主

Rabbit

種屬反應(yīng)性

Rat

靶點(diǎn)

Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH.

基因ID

UniProt ID

總結(jié)

DARPP-32 is a dopamine (DA) and cAMP-regulated ~32k phosphoprotein that is associated with dopaminoceptive neurons (Fienberg et al., 1998). The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA (Bibb et al., 1999). Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac? (Maldve et al., 2002; Lindskog et al., 2002; Svenningsson et al., 2002).

形式

Prepared from rabbit serum by affinity purification via chromatography on an affinity column prepared with the N-terminal peptide used as antigen.

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IHC

稀釋方法

WB~~ 1:1000 IHC~~ 1:250

別名

Protein phosphatase 1 regulatory subunit 1B, DARPP-32, Dopamine- and cAMP-regulated neuronal phosphoprotein, Ppp1r1b

圖像

Westernblot of rat hippocampal lysate showing specific immunolabeling of the ~32k DARPP protein.

Immunochemical staining of cultured CD1 mouse striatal cells showing specific labeling ofDARPP-32 in green and Tuj1 in red. Cells and photo courtesy of QBMCellScience.

說明書

數(shù)量

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