全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR15364G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CDC42BPB / MRCKB antibody (aa1641-1690).
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分子量 |
194kDa
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細胞定位 |
Antigen Cellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42
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宿主 |
Rabbit
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種屬反應性 |
Human, Mouse, Rat
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靶點 |
MRCKB Antibody detects endogenous levels of total MRCKB protein.
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基因ID |
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UniProt ID |
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功能 |
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.
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總結(jié) |
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC-P, E
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稀釋方法 |
ELISA (1:40000), IHC-P (5 μg/ml), WB (1:500-1:1000)
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別名 |
Serine/threonine-protein kinase MRCK beta, 2.7.11.1, CDC42-binding protein kinase beta, CDC42BP-beta, DMPK-like beta, Myotonic dystrophy kinase-related CDC42-binding kinase beta, MRCK beta, Myotonic dystrophy protein kinase-like beta, CDC42BPB {ECO:0000312|EMBL:AAD37506.1}
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圖像 |
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說明書 |
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數(shù)量 |
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