GPR161 Antibody (N-Terminus)

APR16517G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR16517G		50 μg / ￥4950

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安諾倫（北京）生物科技有限公司

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GPR161 Antibody (N-Terminus)

品牌	Leading Biology	貨號(hào)	APR16517G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GPR161 antibody (N-Terminus).
分子量	59kDa
細(xì)胞定位	Antigen Cellular Localization: Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity).
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	Human GPR161. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
基因ID	23432
UniProt ID	Q8N6U8
功能	Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
總結(jié)	Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC-P, ICC
稀釋方法	IHC-P (4-9 μg/ml)
別名	G-protein coupled receptor 161, G-protein coupled receptor RE2, GPR161
圖像	Anti-GPR161 antibody IHC of human Lung, Adenocarcinoma. Anti-GPR161 antibody APR16517G IHC of human brain, pituitary.
說明書	Product Datasheet Protocol
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