全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR09237G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Thr305 CaM Kinase II antibody.
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分子量 |
50/60 KDa
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Rat
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靶點 |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr305 conjugated to KLH.
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基因ID |
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UniProt ID |
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總結(jié) |
Ca2+/Calmodulin-Dependent Protein Kinase II (CaM Kinase II) is amulti-functional calcium and calmodulin-dependent protein kinase that mediates cellularresponses to a wide variety of intercellular signals (Kennedy, 1998; Schulman and Hanson,1993). CaM Kinase II has been shown to regulate diverse cellular functions including synapticplasticity, neurotransmitter synthesis and release, gene expression, ion channel function,carbohydrate metabolism, cytoskeletal function, and Ca2+-homeostasis (Gleason et al., 2003;Soderling, 2000; Hudmon and Schulman, 2002). Phosphorylation of Thr286 on the kinaseproduces an autonomously active form of CaM Kinase II (Meng et al., 2003; Picciotto et al.,1993). Autophosphorylation of Thr305 inhibits the activity of CaM Kinase II. Phosphorylation atthis site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP andlearning (Elgersma et al., 2002).
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形式 |
Unpurified neat serum.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~ 1:1000
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別名 |
Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, Camk2a
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圖像 |
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說明書 |
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數(shù)量 |
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