SIAH1 antibody - N-terminal region

APR13337G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR13337G		100 μg / ￥4950

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SIAH1 antibody - N-terminal region

品牌	Leading Biology	貨號(hào)	APR13337G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SIAH1 antibody - N-terminal region.
分子量	35 kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat, Rabbit, Zebrafish, Dog, Guinea Pig, Horse, Bovine
靶點(diǎn)	SIAH1 is a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
通用名	HUMSIAH
基因ID	6477
UniProt ID	Q8IUQ4
功能	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S- nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.
總結(jié)	This is a rabbit polyclonal antibody against SIAH1. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).
形式	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
別名	E3 ubiquitin-protein ligase SIAH1, 632-, Seven in absentia homolog 1, Siah-1, Siah-1a, SIAH1, HUMSIAH
圖像	SIAH1 antibody (APR13337G) in Human Heart cells using Immunohistochemistry Rabbit Anti-SIAH1 antibody Catalog Number: APR13337G Paraffin Embedded Tissue: Human Heart cell Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 μg/ml Magnification: 400X SIAH1 antibody - N-terminal region (APR13337G) in Human HEK293T cells using Western Blot Application: Western blotting Species+tissue/cell type: Human embryonic kidney 293T How many ug?€?s of tissue/cell lysate run on the gel:1: 50 ug human HEK-293T cell lysate Primary Antibody Dilution: 1:1000 Secondary Antibody: Anti-rabbit-IgG Secondary Antibody Dilution: 1:5000 SIAH1 is strongly supported by BioGPS gene expression data to be expressed in Human HEK293T cells SIAH1 antibody - N-terminal region (APR13337G) in Human Jurkat cells using Western Blot WB Suggested Anti-SIAH1 Antibody Titration: 1.25μg/ml ELISA Titer: 1:312500 Positive Control: Jurkat cell lysate
說(shuō)明書(shū)	Product Datasheet Protocol
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