SMAD4 antibody - middle region

APR10179G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR10179G		100 μg / ￥4950

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SMAD4 antibody - middle region

品牌	Leading Biology	貨號(hào)	APR10179G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SMAD4 antibody - middle region.
分子量	60 kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R- SMAD. PDPK1 prevents its nuclear translocation in response to TGF- beta
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat, Rabbit, Goat, Dog, Guinea Pig, Horse, Sheep, Bovine
靶點(diǎn)	SMAD4 is one of the Smad family members, which are essential intracellular signalling components of the transforming growth factor-beta (TGF-beta) superfamily. Smad2 and Smad3 are structurally highly similar and mediate TGF-beta signals. Smad4 is distantly related to Smads 2 and 3, and forms a heteromeric complex with Smad2 after TGF-beta or activin stimulation. TGF-beta induces heteromeric complexes of Smads 2, 3 and 4, and their concomitant translocation to the nucleus, which is required for efficient TGF-beta signal transduction
通用名	DPC4, MADH4
基因ID	4089
UniProt ID	Q13485
功能	In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
總結(jié)	This is a rabbit polyclonal antibody against SMAD4. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).
形式	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB
別名	Mothers against decapentaplegic homolog 4, MAD homolog 4, Mothers against DPP homolog 4, Deletion target in pancreatic carcinoma 4, SMAD family member 4, SMAD 4, Smad4, hSMAD4, SMAD4, DPC4, MADH4
圖像	SMAD4 antibody - middle region (APR10179G) in Human U2OS cells using Western Blot Sample Type: Human nuclear cell extracts (30ug) Primary Dilution: 1:1000 Secondary Antibody: anti-Rabbit HRP Secondary Dilution: 1:20000 Image Submitted by: Katarina Luciakova Cancer Research Institute See Customer Feedback tab for detailed information. SMAD4 antibody - middle region (APR10179G) in Human U2OS cells using Western Blot SMAD4 antibody - middle region (APR10179G) validated by WB using U2OS nuclear extracts SMAD4 antibody - middle region (APR10179G) in Human HepG2 cells using Western Blot WB Suggested Anti-SMAD4 Antibody Titration: 1.25μg/ml ELISA Titer: 1:312500 Positive Control: HepG2 cell lysate
說明書	Product Datasheet Protocol
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