品牌 |
Leading Biology | 貨號(hào) |
APG02258G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality BCL2L11 antibody (Center).
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分子量 |
22171 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. Isoform BimL: Mitochondrion. Isoform Bim-alpha1: Mitochondrion.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
134-160 aa
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靶點(diǎn) |
This BCL2L11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-160 amino acids from the Central region of human BCL2L11.
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亞型 |
Rabbit Ig
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通用名 |
BIM
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基因ID |
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UniProt ID |
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功能 |
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
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總結(jié) |
BCL2L11 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, FC, E
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稀釋方法 |
IHC-P~~1:10~50
WB~~1:1000
FC~~1:10~50
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別名 |
Bcl-2-like protein 11, Bcl2-L-11, Bcl2-interacting mediator of cell death, BCL2L11, BIM
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圖像 |
Immunohistochemical analysis of paraffin-embedded H. kidney section using BCL2L11 Antibody (Center)( APG02258G). APG02258G was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining. Western blot analysis of BCL2L11 Antibody (Center) (Cat. APG02258G) in K562, HL-60 cell line lysates (35ug/lane). BCL2L11 (arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human colon carcinoma reacted with BCL2L11 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
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說(shuō)明書(shū) |
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數(shù)量 |
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