Phospho-bcl-2(S70) Antibody

APR09151G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR09151G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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Phospho-bcl-2(S70) Antibody

品牌	Leading Biology	貨號(hào)	APR09151G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-bcl-2(S70) antibody.
分子量	26266 Da
細(xì)胞定位	Antigen Cellular Localization: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	This bcl-2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S70 of human bcl-2.
亞型	Rabbit Ig
基因ID	596
UniProt ID	P10415
功能	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
總結(jié)	This gene encodes an integral outer mitochondrial membraneprotein that blocks the apoptotic death of some cells such aslymphocytes. Constitutive expression of BCL2, such as in the caseof translocation of BCL2 to Ig heavy chain locus, is thought to bethe cause of follicular lymphoma. Two transcript variants, producedby alternate splicing, differ in their C-terminal ends. [providedby RefSeq].
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, DB, E
稀釋方法	DB~~1:500 WB~~1:1000
別名	Apoptosis regulator Bcl-2, BCL2
圖像	Dot blot analysis of Phospho-bcl-2-S70 Antibody Phospho-specific Pab (Cat. APR09151G) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. Western blot analysis of extracts from Jurkat cells,untreated or treated with paclitaxel,using phospho-Bcl2(Ser70)(left) or Bcl2 antibody(right).
說(shuō)明書(shū)	Product Datasheet Protocol
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