CLDN14 Antibody (C-term)

APR11595G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR11595G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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CLDN14 Antibody (C-term)

品牌	Leading Biology	貨號	APR11595G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CLDN14 antibody (C-term).
分子量	25699 Da
細胞定位	Antigen Cellular Localization: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
宿主	Rabbit
種屬反應性	Human
免疫原	172-200 aa
靶點	This CLDN14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the C-terminal region of human CLDN14.
亞型	Rabbit Ig
基因ID	23562
UniProt ID	O95500
功能	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.
總結(jié)	Tight junctions represent one mode of cell-to-celladhesion in epithelial or endothelial cell sheets, formingcontinuous seals around cells and serving as a physical barrier toprevent solutes and water from passing freely through theparacellular space. These junctions are comprised of sets ofcontinuous networking strands in the outwardly facing cytoplasmicleaflet, with complementary grooves in the inwardly facingextracytoplasmic leaflet. The protein encoded by this gene, amember of the claudin family, is an integral membrane protein and acomponent of tight junction strands. The encoded protein also bindsspecifically to the WW domain of Yes-associated protein. Defects inthis gene are the cause of an autosomal recessive form ofnonsyndromic sensorineural deafness. It is also reported that foursynonymous variants in this gene are associated with kidney stonesand reduced bone mineral density. Several transcript variantsencoding the same protein have been found for this gene. [providedby RefSeq].
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB, E
稀釋方法	WB~~1:1000
別名	Claudin-14, CLDN14
圖像	Western blot analysis of lysates from human kidney and liver tissue lysate (from left to right), using CLDN14 Antibody (C-term) ( APR11595G). APR11595G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane. CLDN14 Antibody (C-term) (Cat. APR11595G) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the CLDN14 antibody detected the CLDN14 protein (arrow).
說明書	Product Datasheet Protocol
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