全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM07135G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PHAR4 antibody (C-term).
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分子量 |
78211 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Cell projection, lamellipodium
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
536-565 aa
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靶點(diǎn) |
This PHAR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PHAR4.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
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總結(jié) |
This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Phosphatase and actin regulator 4, PHACTR4
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圖像 |
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說明書 |
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數(shù)量 |
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