CDK5R1(p35) Antibody (C-term)

AMM05734G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM05734G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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CDK5R1(p35) Antibody (C-term)

品牌	Leading Biology	貨號	AMM05734G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CDK5R1(p35) antibody (C-term).
分子量	34060 Da
細(xì)胞定位	Antigen Cellular Localization: Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	272-301 aa
靶點(diǎn)	This CDK5R1(p35) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-301 amino acids from the C-terminal region of human CDK5R1(p35).
亞型	Rabbit Ig
通用名	CDK5R, NCK5A
基因ID	8851
UniProt ID	Q15078
功能	p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
總結(jié)	p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC-P, WB, E
稀釋方法	IHC-P~~1:10~50 WB~~1:1000
別名	Cyclin-dependent kinase 5 activator 1, CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit, Cyclin-dependent kinase 5 activator 1, p35, p35, Cyclin-dependent kinase 5 activator 1, p25, p25, Tau protein kinase II 23 kDa subunit, p23, CDK5R1, CDK5R, NCK5A
圖像	Formalin-fixed and paraffin-embedded human brain tissue reacted with CDK5R1(p35) Antibody (C-term) (Cat. AMM05734G), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. CDK5R1 Antibody (C-term) (Cat. AMM05734G) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the CDK5R1 antibody detected the CDK5R1 protein (arrow).
說明書	Product Datasheet Protocol
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