DMP1 Antibody (N-term)

APR15749G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR15749G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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DMP1 Antibody (N-term)

品牌	Leading Biology	貨號(hào)	APR15749G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DMP1 antibody (N-term).
分子量	55782 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	146-175 aa
靶點(diǎn)	This DMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-175 amino acids from the N-terminal region of human DMP1.
亞型	Rabbit Ig
基因ID	1758
UniProt ID	Q13316
功能	May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
總結(jié)	Dentin matrix acidic phosphoprotein is an extracellularmatrix protein and a member of the small integrin binding ligandN-linked glycoprotein family. This protein, which is critical forproper mineralization of bone and dentin, is present in diversecells of bone and tooth tissues. The protein contains a largenumber of acidic domains, multiple phosphorylation sites, afunctional arg-gly-asp cell attachment sequence, and a DNA bindingdomain. In undifferentiated osteoblasts it is primarily a nuclearprotein that regulates the expression of osteoblast-specific genes.During osteoblast maturation the protein becomes phosphorylated andis exported to the extracellular matrix, where it orchestratesmineralized matrix formation. Mutations in the gene are known tocause autosomal recessive hypophosphatemia, a disease thatmanifests as rickets and osteomalacia. The gene structure isconserved in mammals. Two transcript variants encoding differentisoforms have been described for this gene.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, DMP1
圖像	Anti-DMP1 Antibody (N-term) at 1:1000 dilution + MDA-MB-231 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 56 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
說(shuō)明書	Product Datasheet Protocol
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