RRM2B Antibody (Center)

AMR09782G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMR09782G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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RRM2B Antibody (Center)

品牌	Leading Biology	貨號(hào)	AMR09782G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RRM2B antibody (Center).
分子量	40737 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	128-157 aa
靶點(diǎn)	This RRM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human RRM2B.
亞型	Rabbit Ig
通用名	P53R2
基因ID	50484
UniProt ID	Q7LG56
功能	Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
總結(jié)	This gene encodes the small subunit of a p53-inducibleribonucleotide reductase. This heterotetrameric enzyme catalyzesthe conversion of ribonucleoside diphosphates todeoxyribonucleoside diphosphates. The product of this reaction isnecessary for DNA synthesis. Mutations in this gene have beenassociated with autosomal recessive mitochondrial DNA depletionsyndrome, autosomal dominant progressive externalophthalmoplegia-5, and mitochondrial neurogastrointestinalencephalopathy. Alternatively spliced transcript variants have beendescribed.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2, RRM2B, P53R2
圖像	RRM2B Antibody (Center) (Cat. AMR09782G) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the RRM2B antibody detected the RRM2B protein (arrow).
說明書	Product Datasheet Protocol
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