KCNQ5 Antibody (C-term)

AMM06166G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM06166G		100 μl / ￥4950

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KCNQ5 Antibody (C-term)

品牌	Leading Biology	貨號(hào)	AMM06166G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KCNQ5 antibody (C-term).
分子量	102179 Da
細(xì)胞定位	Antigen Cellular Localization: Membrane; Multi-pass membrane protein.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
免疫原	781-809 aa
靶點(diǎn)	This KCNQ5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 781-809 amino acids from the C-terminal region of human KCNQ5.
亞型	Rabbit Ig
基因ID	56479
UniProt ID	Q9NR82
功能	Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.
總結(jié)	This gene is a member of the KCNQ potassium channel genefamily that is differentially expressed in subregions of the brainand in skeletal muscle. The protein encoded by this gene yieldscurrents that activate slowly with depolarization and can formheteromeric channels with the protein encoded by the KCNQ3 gene.Currents expressed from this protein have voltage dependences andinhibitor sensitivities in common with M-currents. They are alsoinhibited by M1 muscarinic receptor activation. Multiple transcriptvariants encoding different isoforms have been found for this gene.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Potassium voltage-gated channel subfamily KQT member 5, KQT-like 5, Potassium channel subunit alpha KvLQT5, Voltage-gated potassium channel subunit Kv75, KCNQ5
圖像	Anti-KCNQ5 Antibody (C-term) at 1:1000 dilution + human skeletal muscle lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 102 kDa Blocking/Dilution buffer: 5% NFDM/TBST. KCNQ5 Antibody (C-term) (Cat. AMM06166G) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the KCNQ5 antibody detected the KCNQ5 protein (arrow).
說(shuō)明書(shū)	Product Datasheet Protocol
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