全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR12940G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PPP1R9B antibody (N-term).
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分子量 |
89192 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton. Nucleus. Cell projection, dendritic spine. Cell junction, synapse. Cell junction, adherens junction. Cytoplasm. Cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle membrane. Note=Enriched at synapse and cadherin-based cell- cell adhesion sites. In neurons, both cytosolic and membrane- associated, and highly enriched in the postsynaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin- rich adherens junctions in epithelial cells and in dendritic spines (By similarity). Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
24-53 aa
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靶點(diǎn) |
This PPP1R9B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human PPP1R9B.
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亞型 |
Rabbit Ig
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通用名 |
PPP1R6
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基因ID |
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UniProt ID |
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功能 |
Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha- adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)- induced cell migration.
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總結(jié) |
Spinophilin is a regulatory subunit of proteinphosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highlyenriched in dendritic spines, specialized protrusions fromdendritic shafts that receive most of the excitatory input in thecentral nervous system (Allen et al., 1997 [PubMed9275233]).
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Neurabin-2, Neurabin-II, Protein phosphatase 1 regulatory subunit 9B, Spinophilin, PPP1R9B, PPP1R6
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圖像 |
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說明書 |
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數(shù)量 |
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