Mouse Csk Antibody (C-term)

APR17415G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR17415G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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Mouse Csk Antibody (C-term)

品牌	Leading Biology	貨號(hào)	APR17415G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Csk antibody (C-term).
分子量	50716 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
免疫原	377-404 aa
靶點(diǎn)	This Mouse Csk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-404 amino acids from the C-terminal region of mouse Csk.
亞型	Rabbit Ig
基因ID	12988
UniProt ID	P41241
功能	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
總結(jié)	Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase MPK-2, p50CSK, Csk
圖像	Mouse Csk Antibody (C-term) (Cat. APR17415G) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the Csk antibody detected the Csk protein (arrow). Mouse Csk Antibody (C-term) (Cat. APR17415G) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Csk antibody detected the Csk protein (arrow).
說(shuō)明書(shū)	Product Datasheet Protocol
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