全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM05767G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CHRM2 antibody (Center).
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分子量 |
51715 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
336-364 aa
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靶點 |
This CHRM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the Central region of human CHRM2.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
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總結(jié) |
The muscarinic cholinergic receptors belong to a largerfamily of G protein-coupled receptors. The functional diversity ofthese receptors is defined by the binding of acetylcholine to thesereceptors and includes cellular responses such as adenylate cyclaseinhibition, phosphoinositide degeneration, and potassium channelmediation. Muscarinic receptors influence many effects ofacetylcholine in the central and peripheral nervous system. Themuscarinic cholinergic receptor 2 is involved in mediation ofbradycardia and a decrease in cardiac contractility. Multiplealternatively spliced transcript variants have been described forthis gene.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Muscarinic acetylcholine receptor M2, CHRM2
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圖像 |
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說明書 |
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數(shù)量 |
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