SOCS6 Antibody (N-term)

AMM07945G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMM07945G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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SOCS6 Antibody (N-term)

品牌	Leading Biology	貨號	AMM07945G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SOCS6 antibody (N-term).
分子量	59528 Da
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	40-69 aa
靶點	This SOCS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human SOCS6.
亞型	Rabbit Ig
通用名	CIS4, SOCS4
基因ID	9306
UniProt ID	O14544
功能	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
總結(jié)	The protein encoded by this gene contains a SH2 domain anda CIS homolog domain. The protein thus belongs to thecytokine-induced STAT inhibitor (CIS), also known as suppressor ofcytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI),protein family. CIS family members are known to becytokine-inducible negative regulators of cytokine signaling. Theexpression of this gene can be induced by GM-CSF and EPO inhematopoietic cells. A high expression level of this gene was foundin factor-independent chronic myelogenous leukemia (CML) anderythroleukemia (HEL) cell lines.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	WB~~1:1000 IHC-P~~1:10~50
別名	Suppressor of cytokine signaling 6, SOCS-6, Cytokine-inducible SH2 protein 4, CIS-4, Suppressor of cytokine signaling 4, SOCS-4, SOCS6, CIS4, SOCS4
圖像	SOCS6 Antibody (N-term) (Cat. AMM07945G) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SOCS6 antibody detected the SOCS6 protein (arrow). SOCS6 Antibody (N-term) (AMM07945G)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SOCS6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
說明書	Product Datasheet Protocol
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