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全部產(chǎn)品分類(lèi)
品牌 |
Leading Biology | 貨號(hào) |
APG02599G |
產(chǎn)品分類(lèi) |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CIDEA antibody (C-term).
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分子量 |
24687 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Lipid droplet. Nucleus. Note=Enriched at lipid droplet contact sites. Has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062) {ECO:0000250, ECO:0000269|PubMed:18509062}
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
181-209 aa
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靶點(diǎn) |
This CIDEA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-209 amino acids from the C-terminal region of human CIDEA.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
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總結(jié) |
This gene encodes the homolog of the mouse protein Cideathat has been shown to activate apoptosis. This activation ofapoptosis is inhibited by the DNA fragmentation factor DFF45 butnot by caspase inhibitors. Mice that lack functional Cidea havehigher metabolic rates, higher lipolysis in brown adipose tissueand higher core body temperatures when subjected to cold. Thesemice are also resistant to diet-induced obesity and diabetes. Thissuggests that in mice this gene product plays a role inthermogenesis and lipolysis. Alternatively spliced transcripts havebeen identified.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Cell death activator CIDE-A, Cell death-inducing DFFA-like effector A, CIDEA
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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